Download PDF by Robert Garcea, Daniel DiMaio: The Papillomaviruses

By Robert Garcea, Daniel DiMaio

ISBN-10: 0387365222

ISBN-13: 9780387365220

This quantity bargains an entire description of the present nation of biology about the papillomavirus. It evaluates the carcinogenic possibility to people posed via an infection with human papillomaviruses (HPVs). thus far, greater than 70 HPV varieties were pointed out, of which over 15 were said in cervical melanoma biopsies. around the world, cervical melanoma is the second one most typical melanoma in girls, nearly 500,000+ new situations are clinically determined every year. This publication additionally considers the potential involvement of HPV an infection in cancers at different websites of the human physique.

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1981). , 1983). Although these viruses were present in a high proportion of benign genital warts, related sequences were found in only a minority ∼10% of cervical cancers. , 1984) DNA, two genotypes only distantly related to HPV6/11. It was soon determined that the majority of cervical cancers contained DNA that hybridized under stringent conditions to probes from HPV16 or HPV18. Under less stringent conditions, an even higher proportion of cervical cancers hybridized to these viral DNAs. The findings therefore implicated HPV in a common human cancer.

Natl. Acad. Sci. U S A 80(12):3812–3815. , and Gissmann, L. (1987). Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1:251–256. R. (1980). Focus assay in mouse cells for bovine papillomavirus. Virology 103:369–375. , and Harlow, E. (1989). The human papillomavirus16 E7 oncoprotein is able to bind the retinoblastoma gene product. Science 243:934–937. M. (1983). Transcriptional organization of bovine papillomavirus type 1.

Papillomavirus genomes evolve very slowly, and the phylogenetic tree of all known animal and human papillomavirus types appears to represent a evolutionary history as ancient as that of their hosts, namely, more than 100 million years in the case of all vertebrate papillomaviruses and several hundred thousand years in the case of all the variants of human papillomavirus types. On the taxonomic level of genera, there is only limited correlation between taxonomic classification and molecular biological and pathogenic properties, but on lower taxonomic levels, 29 30 Hans-Ulrich Bernard the papillomavirus types that form one species have similar biological and pathogenic properties.

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The Papillomaviruses by Robert Garcea, Daniel DiMaio


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